Pathogenic concepts currently believe that subtle changes to this microenvironment have pronounced effects on arterial tone and can severely alter peripheral vascular resistance.
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He conducted research in three areas : endothelial control of arterial tone by nitric oxide ( NO ) and endothelium-derived hyperpolarizing factor ( EDHF;, applications of Chaos Theory and nonlinear mathematics in the analysis of microcirculatory perfusion and modelling of the cellular mechanisms that underpin smooth muscle contraction, and applications of computational fluid dynamics and magnetic resonance angiography in large artery haemodynamics.
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